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The impact of TRT

Scientists found that replacement therapy improved the quality of life in men diagnosed with testosterone deficiency.


“It is thought that testosterone treatment in men may increase prostate size and worsen lower urinary tract symptoms,” said Abdulmaged Traish, PhD, professor of urology. He discovered there were fewer urinary symptoms such as frequent urination, incomplete bladder emptying, weak urinary stream and waking up at night to urinate among men that received testosterone therapy.

Testosterone is a steroid hormone involved in the regulation of sexual function, urinary health and metabolism as well as a number of other critical functions.

According to Traish testosterone treatment also increased the scores men received on assessments of their erectile/sexual health and general quality of life.

Traish emphasised the value of testosterone replacement therapy (TRT), stating that, “Testosterone therapy is well-tolerated with progressive and sustained improvement in urinary and sexual function and overall improvement in quality of life.”

Still taboo in society

Traish was part of a team who investigated the long-term impact of testosterone replacement therapy in men who were diagnosed with symptomatic testosterone deficiency. More than 650 men enrolled in the study of which findings appeared in the Journal of Urology.

The study was a collaboration between scientists from America’s Boston University School of Medicine and Public Health and urologists in Germany.

Despite concerns that testosterone treatment may increase prostate size and lead to lower urinary-tract symptoms, these problems were not seen in the study group.

Traish said previous studies that linked the treatment with cardiovascular risk have been debunked and alluded to the fact that a man’s testosterone peaked between the ages of 22 and 45 years. “So why are we not dropping dead left and right from cardiovascular disease?”

For him the focus on cardiovascular disease reflects a wider opposition to the use of testosterone replacement therapy that is more cultural than scientific in nature.

“We still have certain things in our society as taboo. That’s what this is. If we cross out the word testosterone and we call it whatever, people would have less of a problem with that.”

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