By Anthony Roberts
While Muscle Evolution neither condones nor promotes the use of performance enhancing drugs and steroids, we want to foster a culture of safe and responsible use through education, which is why we regularly compile authoritative and trustworthy drug-related information.
Synthetic Growth Hormone
The injectable compound is technically rhGH – GH produced by recombinant DNA (rDNA) technology. It increases circulating insulin-like growth factor 1 (IGF-I) and also causes the synthesis of IGF-I in most non-hepatic tissues, including muscle, which is thought to be a major contributor to its anabolic effect as IGF-I has a profound anabolic effect on protein metabolism – it inhibits whole body protein breakdown and simultaneously stimulates protein synthesis.
- Dosage and application:
- Practical use:
- Side effects:
- Also known as: Growth hormone 1
- Family: 22kDa isomer of a protein-based 191-amino acid single-chain polypeptide hormone
Testing for hGH
While it has traditionally been difficult to test for the use of synthetic GH as it is difficult to distinguish between synthetic and natural GH, the World Anti-Doping Agency (WADA) has been working on two suitable forms of detection. The first form, in use in some form since the 2004 Olympic Games in Athens, is the isoforms test. It measures the ratio of the different types of growth hormone, including those naturally produced by the body and forms that can be produced both by the body and synthetically. If someone is using synthetic GH, the latter part of the ratio increases. The other test, which is in the final stages of redevelopment after being briefly introduced at the 2012 London Olympics, is the hGH Biomarkers Test.
Disclaimer: Muscle Evolution does not condone nor promote the use of performance-enhancing drugs and steroids. The information in this article is provided solely for the purpose of fostering a clearer understanding through education, allowing readers to make informed and responsible decisions.