Pulling the trigger on muscular development
Mechano Growth Factor (MGF) has been described as the in vogue peptide used among bodybuilders as it triggers hypertrophy and repair in muscle tissue damaged during resistance exercise.
As a splice variant of the Insulin-like Growth Factor-1 (IGF-1) gene – referenced as IGF-1Ec – it increases stem cell count in the muscle and allows for muscle fibres to fuse and mature.
MGF is considered the “growth pulse” that activates the initial spark to activate satellite cells.
When muscles are overloaded by weights the IGF-1 gene is released and is spliced during the body’s response, which stimulates satellite cells into activation resulting in extra undamaged nuclei growing new muscle fibre and tissue. Circulating growth hormone (GH) and testosterone levels play key roles in increasing their expression in the muscle. There is a systemic release of the IGF isoform IGF-1Ea from the liver in the human body after the initial splicing of IGF-1 into MGF (IGF-1Ec) which up regulates protein synthesis.
The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is viewed as the primary anabolic mechanism by which the human body produces new muscle.
Available as peptide
MGF is available as an injectable peptide, which is responsible for localised muscle growth after it is injected in recently trained muscle groups to increase cell repair and the proliferation of new cells.
Rodent studies indicate that MGF is a potent inducer of muscle growth. Research has further shown a 20% increase in weight in the muscle fibres injected with MGF within a period of two weeks. Bodybuilders therefore often use MGF to bring up lagging body parts as well as kickstart overall muscle growth.
Apart from intramuscular injections, MGF is also injected subcutaneously (in the stomach, thigh or buttock) using small gauge insulin syringes, where it makes its way to muscle cell receptors.
The half-life of MGF is only a few minutes but dosing is improved by way of pegylation (PegMGF) which essentially helps to provide a protective barrier around an attached protein so it can survive in the body for longer periods of time. Pegylation has been described as similar to the protection of a turtle shell. Pegulation or Peg has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. By synthetically injecting MGF a person will have more at its disposal than what can be released naturally.